p atm (Cell Signaling Technology Inc)
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96
Structured Review
Cell Signaling Technology Inc
p atm
P Atm, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 441 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/phospho+atm+ser1981/Phospho-ATM+(Ser1981)+Rabbit+mAb/pmc12990383-19-0-2
Average 96 stars, based on 441 article reviews
P Atm, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 441 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/phospho+atm+ser1981/Phospho-ATM+(Ser1981)+Rabbit+mAb/pmc12990383-19-0-2
Average 96 stars, based on 441 article reviews
p atm - by Bioz Stars,
2026-09
96/100 stars
Images
1) Product Images from "SKA2 promotes gastric cancer progression by regulating glutathione metabolism"
Article Title: SKA2 promotes gastric cancer progression by regulating glutathione metabolism
Journal: iScience
doi: 10.1016/j.isci.2026.115202
Figure Legend Snippet: Knocking down SKA2-induced cell-cycle arrest and apoptosis through the SKA2/ROS/ATM axis in GC cell lines (A) Western blotting analysis of γ-H2AX (Ser139), ATM, p -ATM (Ser1981), p -Chk2 (Thr68), and SKA2 expression in SNU638 and NUGC3 SKA2-knockdown cell lines. (B) Western blotting analysis of SKA2 overexpression in SNU638 and NUGC3 SKA2-knockdown cell lines using antibodies against γ-H2AX (Ser139), ATM, p -ATM (Ser1981), p -Chk2 (Thr68), and SKA2. (C) Western blotting analysis of KU-55933 treatment in SNU638 and NUGC3 SKA2-knockdown cell lines using antibodies against cyclin D1, cyclin A2, cyclin B1, p -Chk2 (Thr68), PARP, Cleaved-Caspase3, JNK, p -JNK (Thr183/Tyr185), ATM, p -ATM (Ser1981), and SKA2. (D) Western blotting analysis of BML-277 treatment in SNU638 and NUGC3 SKA2-knockdown cell lines using antibodies against cyclin D1, cyclin A2, cyclin B1, p -Chk2 (Thr68), and SKA2. (E) Western blotting analysis of P38, p-P38 (Thr180/Tyr182), ERK, p -ERK1/2 (Thr202/Tyr204), JNK, p -JNK (Thr183/Tyr185), and SKA2 expression in SNU638 and NUGC3 SKA2-knockdown cell lines. (F) Western blotting analysis of the rescue effect of SKA2 overexpression on MAPK pathway markers (ERK, p -ERK1/2, JNK, and p -JNK) in SNU638 and NUGC3 SKA2-knockdown cell lines. (G) Western blotting analysis of JNK-IN-8 treatment in SNU638 SKA2-knockdown cell lines using antibodies against PARP, cleaved-caspase3, JNK, p -JNK (Thr183/Tyr185), and SKA2. α-Tubulin was used as the internal control for all blots. Representative blotting images are shown from 3 independent experiments.
Techniques Used: Western Blot, Expressing, Knockdown, Over Expression, Control
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The following antibodies were used for Western blotting and/or immunostaining: hemagglutinin (HA) tag (Cell Signaling Technology [CST], #2999S); phospho-RPA2 (Ser4/Ser8) (Bethyl Laboratories, A300-245A); phospho-RPA2 (Ser33) (Bethyl Laboratories, A300-246A); RPA2 (CST, #2208S); phospho-CHK1 (Ser296) (CST, #90178S); phospho-CHK1 (Ser317) (CST, #12302S); phospho-CHK1 (Ser345) (CST, #2348S); CHK1 (CST, #2360S); Membrane:Article Title: Targeting miR-4653-3p/SLC25A51/SIRT3 axis to induce synthetic lethality in ARID1A-deficient colorectal cancer via blockade of DNA repair Article Snippet: The prepared protein samples were loaded into the SDS-PAGE gel and transferred onto the PVDF membrane (Millipore, USA). .. After that, 5% defatted milk was added to the blocked membrane for 2 h. Afterward, primary antibodies ARID1A (Cell Signaling Technology, #12354S, 1:1000 dilution), Cleaved-PARP (Cell Signaling Technology, #5625T, 1:1000 dilution) and Cleaved-caspase 3 antibodies (Cell Signaling Technology, #9661T, 1:1000 dilution), SLC25A51 antibody (Biorbyt, #356775, 1:1000 dilution), Incubation:Article Title: Targeting miR-4653-3p/SLC25A51/SIRT3 axis to induce synthetic lethality in ARID1A-deficient colorectal cancer via blockade of DNA repair Article Snippet: The prepared protein samples were loaded into the SDS-PAGE gel and transferred onto the PVDF membrane (Millipore, USA). .. After that, 5% defatted milk was added to the blocked membrane for 2 h. 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The following antibodies were used for Western blotting and/or immunostaining: hemagglutinin (HA) tag (Cell Signaling Technology [CST], #2999S); phospho-RPA2 (Ser4/Ser8) (Bethyl Laboratories, A300-245A); phospho-RPA2 (Ser33) (Bethyl Laboratories, A300-246A); RPA2 (CST, #2208S); phospho-CHK1 (Ser296) (CST, #90178S); phospho-CHK1 (Ser317) (CST, #12302S); phospho-CHK1 (Ser345) (CST, #2348S); CHK1 (CST, #2360S); FLAG-tag:Article Title: CHK1 is an integral regulator of DNA replication in human cells Article Snippet: .. The following antibodies were used for Western blotting and/or immunostaining: hemagglutinin (HA) tag (Cell Signaling Technology [CST], #2999S); phospho-RPA2 (Ser4/Ser8) (Bethyl Laboratories, A300-245A); phospho-RPA2 (Ser33) (Bethyl Laboratories, A300-246A); RPA2 (CST, #2208S); phospho-CHK1 (Ser296) (CST, #90178S); phospho-CHK1 (Ser317) (CST, #12302S); phospho-CHK1 (Ser345) (CST, #2348S); CHK1 (CST, #2360S); |